Bisquick Chicken Mexican Fiesta Casserole

Craving Mexican food but don’t want to spend a lot of time in the kitchen? Bisquick Mexican fiesta casserole is an easy and delicious recipe that will satisfy your cravings. This dish is made with all of your favorite Mexican flavors and is ideal for using chicken or beef in a new way.

You’ll love how simple this recipe is to make – just mix together a few ingredients and bake in the oven. Plus, it’s perfect for any occasion – from weeknight dinners to potlucks and parties. Serve this casserole with a side of chips and guacamole for a complete meal everyone will love.

Have more chicken to use? Check out this jalapeno popper chicken casserole! Or if beef is hat's in the refrigerator, check out the layered burrito casserole or beef tamale casserole. All of these are great flavorful dishes with that Tex-Mex flavor we all love.

spatula of mexican fiesta casserole held above full casserole dish

What Do I Serve With Mexican Fiesta Casserole?

One of my favorite things about this recipe is that it truly is an all-in-one dish. It has starch, protein, and vegetables all together with a bit of cheese on top.

However, if you want to serve this as an entree with side dishes, I would recommend going with something like a side salad, roasted vegetable, or even a classic refried bean. Rice might be nice, but with the starch base, it might be a bit heavy. Of course, classic guacamole with chips is a personal favorite.

square white baking dish of casserole topped with sour cream and herbs

Ingredients

1 tablespoon olive oil (15ml)
10 ounces ground chicken (300g)
1 medium red onion
1 zucchini
½ red bell pepper
1 tablespoon taco seasoning (28g)
½ cup salsa (125g)
½ can chili beans (115g)
1 cup shredded cheddar cheese (83g)
1 cup Bisquick mix (120g)
½ cup buttermilk (120ml)
1 egg

Optional toppings for serving:

Sour cream or plain Greek yogurt
Hot sauce or additional salsa
Chopped green onions, parsley, or fresh cilantro
Lime wedges
Guacamole

white ramekins of ingredients on wood cutting board

Kitchen Tools Used

baking dish of chicken mexican casserole by bowls of peppers

How to Make a Bisquick Chicken Casserole

Spray a 9"x13" baking dish with non-stick spray then set it aside. Then, preheat the oven to 350°F/180°C.

Now, heat the olive oil in a large skillet over medium heat. To the oil, add the chopped red onion, squash or zucchini, and bell pepper. Cook the vegetables, stirring regularly, for about 5 minutes, or until they have softened.

Now, add in the ground chicken and cook it for 8 to 10 minutes or until cooked through. Use a fork or spatula to break up the meat as it cooks.

Then, add the taco seasoning, beans in sauce, and salsa. Stir this together to combine. Taste and add additional spices if desired.

black skillet of peppers and onions with raw chicken being cooked

In a large bowl, whisk together the Bisquick, buttermilk, and egg until a smooth batter forms.

eggs and flour in glass bowl on counter with gray tablecloth

Now, pour that batter into the bottom of the prepared baking dish.

Top this with around ¼ cup of shredded cheese.

Then pour the meat and bean mixture over the top and spread it evenly over the top. Sprinkle the remaining cheese on top of the meat.

meat and beans being spooned into baking dish with wooden spoon

Bake for 30 minutes or until the cheese is melted and golden and the bottom layer is cooked through.

square baking dish of chicken Mexican fiesta casserole topped with sour cream

Chef's Tip

Want to save time in the kitchen? Buy ground meat in bulk and cook it all at once with just salt and pepper to season. Portion into 1 pound bags and freeze for up to 4 months. Then, you can just grab a bag and thaw to throw together with other ingredients to save time cooking when assembling a casserole. This is also a great way to save money by buying at the lowest price on sale!

Like tips like this? Then check out my latest cookbook, The Complete Cookbook for Beginners. This book is filled with essential skills and step-by-step techniques that are ideal for new home cooks.

baking dish of casserole topped with sour cream and fresh herbs on gray napkin

Frequently Asked Questions

Can I Use Different Proteins?

This is a very versatile recipe. I am using ground chicken but you can use just about any meat that you like. Whatever meat you decide to use, you want it to be either ground or shredded.

I love ground or shredded chicken in this recipe. It is also a great way to use up leftover turkey. Sausage is another delicious choice, especially if it is a spicier option like chorizo. If you’d like a vegetarian option, you could use black beans or lentils.

What Can I Use If I Don’t Have Bisquick Mix?

Bisquick mix is readily available in most grocery stores. If you do not have it on hand, you can also use a similar baking mix or even pancake mix. You can also make a homemade version of the baking mix.

How Long is Mexican Fiesta Casserole Good For?

Mexican fiesta casserole can be stored in the refrigerator in an airtight container or tightly covered for up to four days.

When you are ready to eat the Mexican casserole, you can simply reheat it in the oven until warmed through. You can also heat it in the microwave.

Can I Freeze This Bisquick Mexican Casserole?

Yes. The Bisquick Mexican casserole can be frozen for up to 3 months. It can be frozen after it is baked as leftovers. Place it in a freezer-safe container. I like to freeze the leftovers in single-serving portions in freezer bags for convenience.

You can also make this and freeze it before baking. When you are ready to bake it, thaw it overnight in the refrigerator and then bake it according to the instructions below. If you are freezing this casserole as a premade freezer meal, I like to use a disposable casserole dish. This keeps my regular pans in circulation.

Just remember to always label, date, and add cooking directions to any package you put into the freezer.

baking dish of chicken Mexican fiesta casserole on gray tablecloth with bowl of peppers in background

More Chicken Casserole Recipes

Whether it is chicken breast, chicken thighs, or ground chicken like this recipe, you probably have at least 50% of your menu including this always popular protein. If you need more inspiration, below are a few more great recipes that are packed with flavor and ideal for your meal plan!

Yield: 6

Bisquick Chicken Mexican Fiesta Casserole

This Bisquick chicken Mexican fiesta casserole is the perfect weeknight meal! Loaded with tasty flavors, chicken, beans, cheese, and a simple crust!

Prep Time 20 minutes

Cook Time 50 minutes

Total Time 1 hour 10 minutes

Ingredients

1 tablespoon olive oil (15ml)
10 ounces ground chicken (300g)
1 medium red onion, chopped
1 zucchini, chopped
½ red bell pepper, chopped
1 tablespoon taco seasoning (28g)
½ cup salsa (125g)
½ can chili beans, in sauce(115g)
1 cup shredded cheddar cheese (83g)
1 cup Bisquick mix (120g)
½ cup buttermilk (120ml)
1 egg

Optional toppings

Sour cream or plain Greek yogurt
Hot sauce or additional salsa
Chopped green onions, parsley, or fresh cilantro
Lime wedges
Guacamole

Instructions

Preheat the oven to 350°F/180°C and spray a 9" or larger baking dish with non-stick spray then set it aside.
In a large skillet, heat olive oil over medium heat. Add the chopped onion, bell pepper, and squash. Cook, stirring regularly, for 5 minutes until softened.
To the skillet, add the ground meat. Cook this for 8 to 10 minutes, breaking up the meat as it cooks, until it is no longer pink and cooked through.
Add the taco seasoning, beans, and salsa to the skillet and stir to combine then set aside.
In a large bowl, whisk together the Bisquick mix, buttermilk, and egg until a smooth batter forms.
Pour the batter into the prepared baking dish, spreading it evenly over the pan.
Top this with ¼ cup of shredded cheese.
Then, spread the chicken and bean mixture over the top in an even layer.
Top with the remaining cheese then bake it for 30 minutes until it is cooked through and the cheese is melted and golden on top.